6NEE

Crystal structure of a reconstructed ancestor of Triosephosphate isomerase from eukaryotes

6NEE の概要

• エントリーDOI: 10.2210/pdb6nee/pdb
• 分子名称: TRIOSEPHOSPHATE ISOMERASE, PHOSPHOGLYCOLOHYDROXAMIC ACID (3 entities in total)
• 機能のキーワード: isomerase, glycolisis, tim barrel, ancestral sequence reconstruction
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55419.46

構造登録者

Rodriguez-Romero, A.,Schulte-Sasse, M.,Fernandez-Velasco, D.A. (登録日: 2018-12-17, 公開日: 2019-01-09, 最終更新日: 2023-10-11)

• 主引用文献: Schulte-Sasse, M.,Pardo-Avila, F.,Pulido-Mayoral, N.O.,Vazquez-Lobo, A.,Costas, M.,Garcia-Hernandez, E.,Rodriguez-Romero, A.,Fernandez-Velasco, D.A.; Structural, thermodynamic and catalytic characterization of an ancestral triosephosphate isomerase reveal early evolutionary coupling between monomer association and function.; FEBS J., 286:882-900, 2019; PubMed: 30589511; DOI: 10.1111/febs.14741

実験手法

X-RAY DIFFRACTION (1.9 Å)