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6ND5

Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution

This is a non-PDB format compatible entry.
Summary for 6ND5
Entry DOI10.2210/pdb6nd5/pdb
Descriptor23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
Functional Keywordschloramphenicol, erythromycin, competition, antibiotic, 70s ribosome, inhibition of translation, peptidyl transferase center, nascent peptide exit tunnel, ribosome, ribosome-antibiotic complex, ribosome/antibiotic
Biological sourceEscherichia coli
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Total number of polymer chains112
Total formula weight4571677.03
Authors
Svetlov, M.S.,Plessa, E.,Chen, C.-W.,Bougas, A.,Krokidis, M.G.,Dinos, G.P.,Polikanov, Y.S. (deposition date: 2018-12-13, release date: 2019-03-20, Last modification date: 2023-11-15)
Primary citationSvetlov, M.S.,Plessa, E.,Chen, C.W.,Bougas, A.,Krokidis, M.G.,Dinos, G.P.,Polikanov, Y.S.
High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition.
RNA, 25:600-606, 2019
Cited by
PubMed: 30733327
DOI: 10.1261/rna.069260.118
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

數據於2024-03-27公開中

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