6NAH

Crystal structure of Neisseria meningitidis ClpP protease in complex with Acyldepsipeptide-14 (ADEP-14)

6NAH の概要

• エントリーDOI: 10.2210/pdb6nah/pdb
• 分子名称: ATP-dependent Clp protease proteolytic subunit, Acyldepsipeptide-14, OCTANOIC ACID (CAPRYLIC ACID), ... (4 entities in total)
• 機能のキーワード: serine protease, antibiotic, anticancer, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Neisseria meningitidis; 詳細
• タンパク質・核酸の鎖数: 56
• 化学式量合計: 706936.02

構造登録者

Mabanglo, M.F.,Houry, W.A. (登録日: 2018-12-05, 公開日: 2019-11-13, 最終更新日: 2023-11-15)

• 主引用文献: Mabanglo, M.F.,Leung, E.,Vahidi, S.,Seraphim, T.V.,Eger, B.T.,Bryson, S.,Bhandari, V.,Zhou, J.L.,Mao, Y.Q.,Rizzolo, K.,Barghash, M.M.,Goodreid, J.D.,Phanse, S.,Babu, M.,Barbosa, L.R.S.,Ramos, C.H.I.,Batey, R.A.,Kay, L.E.,Pai, E.F.,Houry, W.A.; ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores.; Commun Biol, 2:410-410, 2019; PubMed: 31925204; DOI: 10.1038/s42003-019-0656-3

実験手法

X-RAY DIFFRACTION (2.7 Å)