6N9D

Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/L133P/L151C/G154A) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)

6N9D の概要

• エントリーDOI: 10.2210/pdb6n9d/pdb
• 分子名称: Stromelysin-1, Metalloproteinase inhibitor 1, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: tissue inhibitor of metalloproteinases, matrix metalloproteinase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39511.44

構造登録者

Raeeszadeh-Sarmazdeh, M.,Radisky, E.S.,Sankaran, B. (登録日: 2018-12-03, 公開日: 2019-05-15, 最終更新日: 2023-10-11)

• 主引用文献: Raeeszadeh-Sarmazdeh, M.,Greene, K.A.,Sankaran, B.,Downey, G.P.,Radisky, D.C.,Radisky, E.S.; Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition.; J.Biol.Chem., 294:9476-9488, 2019; PubMed: 31040180; DOI: 10.1074/jbc.RA119.008321

実験手法

X-RAY DIFFRACTION (2.67 Å)