6N96

Methylmalonyl-CoA decarboxylase in complex with 2-sulfonate-propionyl-oxa(dethia)-CoA

6N96 の概要

• エントリーDOI: 10.2210/pdb6n96/pdb
• 関連するPDBエントリー: 1EF8 1EF9
• 分子名称: Methylmalonyl-CoA decarboxylase, (2~{S})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid, (2~{R})-1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethoxy]-1-oxidanylidene-propane-2-sulfonic acid, ... (5 entities in total)
• 機能のキーワード: crotonase, beta-keto, isostere, lyase
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 187638.76

構造登録者

Stunkard, L.M.,Dixon, A.D.,Huth, T.J.,Lohman, J.R. (登録日: 2018-11-30, 公開日: 2019-04-10, 最終更新日: 2023-10-11)

• 主引用文献: Stunkard, L.M.,Dixon, A.D.,Huth, T.J.,Lohman, J.R.; Sulfonate/Nitro Bearing Methylmalonyl-Thioester Isosteres Applied to Methylmalonyl-CoA Decarboxylase Structure-Function Studies.; J. Am. Chem. Soc., 141:5121-5124, 2019; PubMed: 30869886; DOI: 10.1021/jacs.9b00650

実験手法

X-RAY DIFFRACTION (1.7 Å)