6N5W

Crystal structure of the Ca2+/CaM complex with independent peptides of Kv7.4 (KCNQ4) A & B domains

Summary for 6N5W

DescriptorPotassium voltage-gated channel subfamily KQT member 4, Calmodulin-1, CALCIUM ION, ... (5 entities in total)
Functional Keywordsion channel, calmodulin, kcnq4 peptides, complex, metal binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight23216.27
Authors
Taylor, A.B.,Archer, C.R.,Shapiro, M.S. (deposition date: 2018-11-22, release date: 2019-03-13)
Primary citation
Archer, C.R.,Enslow, B.T.,Taylor, A.B.,De la Rosa, V.,Bhattacharya, A.,Shapiro, M.S.
A mutually-induced conformational fit underlies Ca2+-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K+channels.
J. Biol. Chem., 2019
PubMed: 30808708 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.006857
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27490 1.2% 6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6n5w
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Molmil generated image of 6n5w
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Molmil generated image of 6n5w
rotated about y axis by 90°