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6N4N

Crystal structure of the designed protein DNCR2/danoprevir/NS3a complex

Summary for 6N4N
Entry DOI10.2210/pdb6n4n/pdb
DescriptorNS3 protease, Rosetta-designed danoprevir/NS3a complex reader 2, ZINC ION, ... (6 entities in total)
Functional Keywordsrosetta design, procisir, ns3a, danoprevir, de novo protein-hydrolase-inhibitor complex, de novo protein/hydrolase/inhibitor
Biological sourceHepacivirus C (Hepatitis C virus)
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Total number of polymer chains4
Total formula weight95356.75
Authors
Wang, Z.,Foight, G.W.,Baker, D.,Maly, D.J. (deposition date: 2018-11-19, release date: 2019-09-11, Last modification date: 2023-10-11)
Primary citationFoight, G.W.,Wang, Z.,Wei, C.T.,Jr Greisen, P.,Warner, K.M.,Cunningham-Bryant, D.,Park, K.,Brunette, T.J.,Sheffler, W.,Baker, D.,Maly, D.J.
Multi-input chemical control of protein dimerization for programming graded cellular responses.
Nat.Biotechnol., 37:1209-1216, 2019
Cited by
PubMed: 31501561
DOI: 10.1038/s41587-019-0242-8
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.29 Å)
Structure validation

217705

數據於2024-03-27公開中

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