6N4N
Crystal structure of the designed protein DNCR2/danoprevir/NS3a complex
Summary for 6N4N
Entry DOI | 10.2210/pdb6n4n/pdb |
Descriptor | NS3 protease, Rosetta-designed danoprevir/NS3a complex reader 2, ZINC ION, ... (6 entities in total) |
Functional Keywords | rosetta design, procisir, ns3a, danoprevir, de novo protein-hydrolase-inhibitor complex, de novo protein/hydrolase/inhibitor |
Biological source | Hepacivirus C (Hepatitis C virus) More |
Total number of polymer chains | 4 |
Total formula weight | 95356.75 |
Authors | Wang, Z.,Foight, G.W.,Baker, D.,Maly, D.J. (deposition date: 2018-11-19, release date: 2019-09-11, Last modification date: 2023-10-11) |
Primary citation | Foight, G.W.,Wang, Z.,Wei, C.T.,Jr Greisen, P.,Warner, K.M.,Cunningham-Bryant, D.,Park, K.,Brunette, T.J.,Sheffler, W.,Baker, D.,Maly, D.J. Multi-input chemical control of protein dimerization for programming graded cellular responses. Nat.Biotechnol., 37:1209-1216, 2019 Cited by PubMed: 31501561DOI: 10.1038/s41587-019-0242-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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