6N3F

Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5

Summary for 6N3F

Entry DOI	10.2210/pdb6n3f/pdb
Descriptor	HIV Tat-specific factor 1, SF3b1 U2AF ligand motif, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	hiv tat-specific factor 1, tat-sf1, rna splicing factor, u2af homology motif, uhm, rna binding protein, u2af ligand motif, ulm, protein-peptide complex, pre-mrna splicing factor, sf3b1, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	23196.99
Authors	Leach, J.R.,Jenkins, J.L.,Kielkopf, C.L. (deposition date: 2018-11-15, release date: 2019-01-02, Last modification date: 2024-03-13)
Primary citation	Loerch, S.,Leach, J.R.,Horner, S.W.,Maji, D.,Jenkins, J.L.,Pulvino, M.J.,Kielkopf, C.L. The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294:2892-2902, 2019 Cited by PubMed: 30567737 DOI: 10.1074/jbc.RA118.006764 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.099 Å)

Structure validation