6N2R

Binary complex crystal structure of DNA polymerase Beta with 5-carboxy-dC (5-caC) at the templating position

6N2R の概要

• エントリーDOI: 10.2210/pdb6n2r/pdb
• 分子名称: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(1CC)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (6 entities in total)
• 機能のキーワード: dna polymerase beta, conformational change, enzyme mechanism, epigenetic modifications, gene regulation, gene regulation-dna complex, gene regulation/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 47757.84

構造登録者

Batra, V.K.,Wilson, S.H. (登録日: 2018-11-14, 公開日: 2019-04-03, 最終更新日: 2023-10-11)

• 主引用文献: Howard, M.J.,Foley, K.G.,Shock, D.D.,Batra, V.K.,Wilson, S.H.; Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase beta.; J.Biol.Chem., 294:7194-7201, 2019; PubMed: 30885943; DOI: 10.1074/jbc.RA118.006809

実験手法

X-RAY DIFFRACTION (2.1 Å)