6N04

The X-ray crystal structure of AbsH3, an FAD dependent reductase from the Abyssomicin biosynthesis pathway in Streptomyces

6N04 の概要

• エントリーDOI: 10.2210/pdb6n04/pdb
• 分子名称: AbsH3, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, biosynthesis, abyssomicin, structural genomics, psi-biology, protein structure initiative, enzyme discovery for natural product biosynthesis, natpro, biosynthetic protein
• 由来する生物種: Streptomyces sp. LC-6-2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93823.35

構造登録者

Clinger, J.A.,Wang, X.,Cai, W.,Miller, M.D.,Van Lanen, S.G.,Thorson, J.S.,Phillips Jr., G.N.,Enzyme Discovery for Natural Product Biosynthesis (NatPro) (登録日: 2018-11-06, 公開日: 2019-11-13, 最終更新日: 2023-10-11)

主引用文献

Clinger, J.A.,Wang, X.,Cai, W.,Zhu, Y.,Miller, M.D.,Zhan, C.G.,Van Lanen, S.G.,Thorson, J.S.,Phillips Jr., G.N.
The crystal structure of AbsH3: A putative flavin adenine dinucleotide-dependent reductase in the abyssomicin biosynthesis pathway.
Proteins, 2020

PubMed Abstract: Natural products and natural product-derived compounds have been widely used for pharmaceuticals for many years, and the search for new natural products that may have interesting activity is ongoing. Abyssomicins are natural product molecules that have antibiotic activity via inhibition of the folate synthesis pathway in microbiota. These compounds also appear to undergo a required [4 + 2] cycloaddition in their biosynthetic pathway. Here we report the structure of an flavin adenine dinucleotide-dependent reductase, AbsH3, from the biosynthetic gene cluster of novel abyssomicins found in Streptomyces sp. LC-6-2.

PubMed: 32852843
DOI: 10.1002/prot.25994

実験手法

X-RAY DIFFRACTION (1.998 Å)