6MY4
Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98M,HC-G99M,LC-S30bR]
Summary for 6MY4
Entry DOI | 10.2210/pdb6my4/pdb |
Related | 6MXR 6MXS 6MY5 |
Descriptor | anti-VEGF-A Fab fragment bH1 heavy chain, anti-VEGF-A Fab fragment bH1 light chain, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | fab fragment, antibody assembly, dimeric fab, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 99270.85 |
Authors | Shi, R.,Picard, M.-E.,Manenda, M. (deposition date: 2018-11-01, release date: 2019-07-31, Last modification date: 2023-10-11) |
Primary citation | Schrag, J.D.,Picard, M.E.,Gaudreault, F.,Gagnon, L.P.,Baardsnes, J.,Manenda, M.S.,Sheff, J.,Deprez, C.,Baptista, C.,Hogues, H.,Kelly, J.F.,Purisima, E.O.,Shi, R.,Sulea, T. Binding symmetry and surface flexibility mediate antibody self-association. Mabs, 11:1300-1318, 2019 Cited by PubMed: 31318308DOI: 10.1080/19420862.2019.1632114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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