6MY0

Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations

Summary for 6MY0

Entry DOI	10.2210/pdb6my0/pdb
Descriptor	TP53-binding protein 1 (2 entities in total)
Functional Keywords	53bp1, dna damage response, dna double-strand breaks, tudor domain, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	27823.59
Authors	Cui, G.,Botuyan, M.V.,Mer, G. (deposition date: 2018-10-31, release date: 2019-11-27, Last modification date: 2023-10-11)
Primary citation	Cui, G.,Botuyan, M.V.,Drane, P.,Hu, Q.,Bragantini, B.,Thompson, J.R.,Schuller, D.J.,Detappe, A.,Perfetti, M.T.,James, L.I.,Frye, S.V.,Chowdhury, D.,Mer, G. An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14:6091-6091, 2023 Cited by PubMed: 37773238 DOI: 10.1038/s41467-023-41821-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation