6MXX

Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991

Summary for 6MXX

• Entry DOI: 10.2210/pdb6mxx/pdb
• Descriptor: TP53-binding protein 1, PHOSPHATE ION, N-[3-(tert-butylamino)propyl]-3-iodobenzamide, ... (5 entities in total)
• Functional Keywords: 53bp1, tandem tudor domains, small molecule inhibitor, dna damage response, class switch recombination, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 10
• Total formula weight: 143427.46

Authors

Cui, G.,Botuyan, M.V.,Mer, G. (deposition date: 2018-10-31, release date: 2019-11-27, Last modification date: 2023-10-11)

• Primary citation: Cui, G.,Botuyan, M.V.,Drane, P.,Hu, Q.,Bragantini, B.,Thompson, J.R.,Schuller, D.J.,Detappe, A.,Perfetti, M.T.,James, L.I.,Frye, S.V.,Chowdhury, D.,Mer, G.; An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.; Nat Commun, 14:6091-6091, 2023; PubMed: 37773238; DOI: 10.1038/s41467-023-41821-6

Experimental method

X-RAY DIFFRACTION (2.298 Å)