6MXS

Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98F,HC-G99M]

Summary for 6MXS

• Entry DOI: 10.2210/pdb6mxs/pdb
• Related: 6MXR 6MY4 6MY5
• Descriptor: anti-VEGF-A Fab fragment bH1 heavy chain, anti-VEGF-A Fab fragment bH1 light chain, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: fab fragment, antibody assembly, aggregation, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 99008.20

Authors

Shi, R.,Picard, M.-E.,Manenda, M.S. (deposition date: 2018-10-31, release date: 2019-07-31, Last modification date: 2023-10-11)

• Primary citation: Schrag, J.D.,Picard, M.E.,Gaudreault, F.,Gagnon, L.P.,Baardsnes, J.,Manenda, M.S.,Sheff, J.,Deprez, C.,Baptista, C.,Hogues, H.,Kelly, J.F.,Purisima, E.O.,Shi, R.,Sulea, T.; Binding symmetry and surface flexibility mediate antibody self-association.; Mabs, 11:1300-1318, 2019; PubMed: 31318308; DOI: 10.1080/19420862.2019.1632114

Experimental method

X-RAY DIFFRACTION (1.95 Å)