6MX3

Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 1

Summary for 6MX3

• Entry DOI: 10.2210/pdb6mx3/pdb
• Descriptor: Stimulator of interferon genes protein, (3S,4S)-2-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: innate immunity, signaling, open conformation, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 43955.43

Authors

Lesburg, C.A.,Siu, T.,Ho, T. (deposition date: 2018-10-30, release date: 2018-12-19, Last modification date: 2024-03-06)

• Primary citation: Siu, T.,Altman, M.D.,Baltus, G.A.,Childers, M.,Ellis, J.M.,Gunaydin, H.,Hatch, H.,Ho, T.,Jewell, J.,Lacey, B.M.,Lesburg, C.A.,Pan, B.S.,Sauvagnat, B.,Schroeder, G.K.,Xu, S.; Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.; ACS Med Chem Lett, 10:92-97, 2019; PubMed: 30655953; DOI: 10.1021/acsmedchemlett.8b00466

Experimental method

X-RAY DIFFRACTION (1.362 Å)