6MUM

Murine PI3K delta kinsae domain - cpd 3

Summary for 6MUM

• Entry DOI: 10.2210/pdb6mum/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, [(3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidin-1-yl](oxan-4-yl)methanone (2 entities in total)
• Functional Keywords: phosphoinositide 3-kinase, isoform-specific inhibitors, transferase, inflammatory disorders
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 216526.35

Authors

Fischmann, T.O. (deposition date: 2018-10-23, release date: 2019-05-01, Last modification date: 2023-10-11)

• Primary citation: Methot, J.L.,Zhou, H.,Kattar, S.D.,McGowan, M.A.,Wilson, K.,Garcia, Y.,Deng, Y.,Altman, M.,Fradera, X.,Lesburg, C.,Fischmann, T.,Li, C.,Alves, S.,Shah, S.,Fernandez, R.,Goldenblatt, P.,Hill, A.,Shaffer, L.,Chen, D.,Tong, V.,McLeod, R.L.,Yu, H.,Bass, A.,Kemper, R.,Gatto, N.T.,LaFranco-Scheuch, L.,Trotter, B.W.,Guzi, T.,Katz, J.D.; Structure Overhaul Affords a Potent Purine PI3K delta Inhibitor with Improved Tolerability.; J.Med.Chem., 62:4370-4382, 2019; PubMed: 30986068; DOI: 10.1021/acs.jmedchem.8b01818

Experimental method

X-RAY DIFFRACTION (3.06 Å)