6MUL

Murine PI3K delta kinsae domain - cpd 1

6MUL の概要

• エントリーDOI: 10.2210/pdb6mul/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 1-{1-[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]piperidin-4-yl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (2 entities in total)
• 機能のキーワード: phosphoinositide 3-kinase, isoform-specific inhibitors, transferase, inflammatory disorders
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 216564.37

構造登録者

Fischmann, T.O. (登録日: 2018-10-23, 公開日: 2019-05-01, 最終更新日: 2023-10-11)

• 主引用文献: Methot, J.L.,Zhou, H.,Kattar, S.D.,McGowan, M.A.,Wilson, K.,Garcia, Y.,Deng, Y.,Altman, M.,Fradera, X.,Lesburg, C.,Fischmann, T.,Li, C.,Alves, S.,Shah, S.,Fernandez, R.,Goldenblatt, P.,Hill, A.,Shaffer, L.,Chen, D.,Tong, V.,McLeod, R.L.,Yu, H.,Bass, A.,Kemper, R.,Gatto, N.T.,LaFranco-Scheuch, L.,Trotter, B.W.,Guzi, T.,Katz, J.D.; Structure Overhaul Affords a Potent Purine PI3K delta Inhibitor with Improved Tolerability.; J.Med.Chem., 62:4370-4382, 2019; PubMed: 30986068; DOI: 10.1021/acs.jmedchem.8b01818

実験手法

X-RAY DIFFRACTION (3.09 Å)