6MTR

Crystal structure of VRC43.01 Fab

6MTR の概要

• エントリーDOI: 10.2210/pdb6mtr/pdb
• 分子名称: Antibody VRC43.01 Fab heavy chain, Antibody VRC43.01 Fab light chain (3 entities in total)
• 機能のキーワード: anti-hiv-1 human antibody, mper, gp41, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47258.77

構造登録者

Kwon, Y.D.,Druz, A.,Law, W.H.,Peng, D.,Zhang, B.,Doria-Rose, N.A.,Kwong, P.D. (登録日: 2018-10-21, 公開日: 2019-03-27, 最終更新日: 2024-04-03)

• 主引用文献: Krebs, S.J.,Kwon, Y.D.,Schramm, C.A.,Law, W.H.,Donofrio, G.,Zhou, K.H.,Gift, S.,Dussupt, V.,Georgiev, I.S.,Schatzle, S.,McDaniel, J.R.,Lai, Y.T.,Sastry, M.,Zhang, B.,Jarosinski, M.C.,Ransier, A.,Chenine, A.L.,Asokan, M.,Bailer, R.T.,Bose, M.,Cagigi, A.,Cale, E.M.,Chuang, G.Y.,Darko, S.,Driscoll, J.I.,Druz, A.,Gorman, J.,Laboune, F.,Louder, M.K.,McKee, K.,Mendez, L.,Moody, M.A.,O'Sullivan, A.M.,Owen, C.,Peng, D.,Rawi, R.,Sanders-Buell, E.,Shen, C.H.,Shiakolas, A.R.,Stephens, T.,Tsybovsky, Y.,Tucker, C.,Verardi, R.,Wang, K.,Zhou, J.,Zhou, T.,Georgiou, G.,Alam, S.M.,Haynes, B.F.,Rolland, M.,Matyas, G.R.,Polonis, V.R.,McDermott, A.B.,Douek, D.C.,Shapiro, L.,Tovanabutra, S.,Michael, N.L.,Mascola, J.R.,Robb, M.L.,Kwong, P.D.,Doria-Rose, N.A.; Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.; Immunity, 50:677-691.e13, 2019; PubMed: 30876875; DOI: 10.1016/j.immuni.2019.02.008

実験手法

X-RAY DIFFRACTION (1.798 Å)