6MTO

Crystal structure of VRC42.01 Fab in complex with T117-F MPER scaffold

Summary for 6MTO

• Entry DOI: 10.2210/pdb6mto/pdb
• Descriptor: Antibody VRC42.01 Fab light chain, Antibody VRC42.01 Fab heavy chain, VRC42 epitope T117-F scaffold, ... (4 entities in total)
• Functional Keywords: anti-hiv-1 human antibody, mper, gp41, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 65419.48

Authors

Kwon, Y.D.,Druz, A.,Law, W.H.,Peng, D.,Zhang, B.,Doria-Rose, N.A.,Kwong, P.D. (deposition date: 2018-10-21, release date: 2019-03-27, Last modification date: 2023-10-11)

• Primary citation: Krebs, S.J.,Kwon, Y.D.,Schramm, C.A.,Law, W.H.,Donofrio, G.,Zhou, K.H.,Gift, S.,Dussupt, V.,Georgiev, I.S.,Schatzle, S.,McDaniel, J.R.,Lai, Y.T.,Sastry, M.,Zhang, B.,Jarosinski, M.C.,Ransier, A.,Chenine, A.L.,Asokan, M.,Bailer, R.T.,Bose, M.,Cagigi, A.,Cale, E.M.,Chuang, G.Y.,Darko, S.,Driscoll, J.I.,Druz, A.,Gorman, J.,Laboune, F.,Louder, M.K.,McKee, K.,Mendez, L.,Moody, M.A.,O'Sullivan, A.M.,Owen, C.,Peng, D.,Rawi, R.,Sanders-Buell, E.,Shen, C.H.,Shiakolas, A.R.,Stephens, T.,Tsybovsky, Y.,Tucker, C.,Verardi, R.,Wang, K.,Zhou, J.,Zhou, T.,Georgiou, G.,Alam, S.M.,Haynes, B.F.,Rolland, M.,Matyas, G.R.,Polonis, V.R.,McDermott, A.B.,Douek, D.C.,Shapiro, L.,Tovanabutra, S.,Michael, N.L.,Mascola, J.R.,Robb, M.L.,Kwong, P.D.,Doria-Rose, N.A.; Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.; Immunity, 50:677-691.e13, 2019; PubMed: 30876875; DOI: 10.1016/j.immuni.2019.02.008

Experimental method

X-RAY DIFFRACTION (2.634 Å)