6MQS

Vaccine-elicited NHP FP-targeting HIV neutralizing antibody A12V163-a.01 in complex with HIV fusion peptide (residue 512-519)

Summary for 6MQS

• Entry DOI: 10.2210/pdb6mqs/pdb
• Descriptor: antibody A12V163-a.01 heavy chain, antibody A12V163-a.01 light chain, HIV fusion peptide residue 512-519 (3 entities in total)
• Functional Keywords: hiv, neutralizing, nhp, fp, fusion peptide, vaccine, immune system
• Biological source: Macaca mulatta; More
• Total number of polymer chains: 6
• Total formula weight: 95079.52

Authors

Xu, K.,Wang, Y.,Kwong, P.D. (deposition date: 2018-10-10, release date: 2019-07-31, Last modification date: 2019-11-13)

• Primary citation: Kong, R.,Duan, H.,Sheng, Z.,Xu, K.,Acharya, P.,Chen, X.,Cheng, C.,Dingens, A.S.,Gorman, J.,Sastry, M.,Shen, C.H.,Zhang, B.,Zhou, T.,Chuang, G.Y.,Chao, C.W.,Gu, Y.,Jafari, A.J.,Louder, M.K.,O'Dell, S.,Rowshan, A.P.,Viox, E.G.,Wang, Y.,Choi, C.W.,Corcoran, M.M.,Corrigan, A.R.,Dandey, V.P.,Eng, E.T.,Geng, H.,Foulds, K.E.,Guo, Y.,Kwon, Y.D.,Lin, B.,Liu, K.,Mason, R.D.,Nason, M.C.,Ohr, T.Y.,Ou, L.,Rawi, R.,Sarfo, E.K.,Schon, A.,Todd, J.P.,Wang, S.,Wei, H.,Wu, W.,Mullikin, J.C.,Bailer, R.T.,Doria-Rose, N.A.,Karlsson Hedestam, G.B.,Scorpio, D.G.,Overbaugh, J.,Bloom, J.D.,Carragher, B.,Potter, C.S.,Shapiro, L.,Kwong, P.D.,Mascola, J.R.; Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.; Cell, 178:567-584.e19, 2019; PubMed: 31348886; DOI: 10.1016/j.cell.2019.06.030

Experimental method

X-RAY DIFFRACTION (2.997 Å)