6MQO
Structure of HIV-1 CA G208R
Summary for 6MQO
| Entry DOI | 10.2210/pdb6mqo/pdb |
| Descriptor | Capsid protein, IODIDE ION (3 entities in total) |
| Functional Keywords | capsid, viral protein |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 1 |
| Total formula weight | 26115.57 |
| Authors | Smaga, S.S.,Xiong, Y. (deposition date: 2018-10-10, release date: 2019-06-19, Last modification date: 2024-10-23) |
| Primary citation | Smaga, S.S.,Xu, C.,Summers, B.J.,Digianantonio, K.M.,Perilla, J.R.,Xiong, Y. MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid. Structure, 27:1234-, 2019 Cited by PubMed Abstract: The human antiviral protein MxB is a restriction factor that fights HIV infection. Previous experiments have demonstrated that MxB targets the HIV capsid, a protein shell that protects the viral genome. To make the conical-shaped capsid, HIV CA proteins are organized into a lattice composed of hexamer and pentamer building blocks, providing many interfaces for host proteins to recognize. Through extensive biochemical and biophysical studies and molecular dynamics simulations, we show that MxB is targeting the HIV capsid by recognizing the region created at the intersection of three CA hexamers. We are further able to map this interaction to a few CA residues, located in a negatively charged well at the interface between the three CA hexamers. This work provides detailed residue-level mapping of the targeted capsid interface and how MxB interacts. This information could inspire the development of capsid-targeting therapies for HIV. PubMed: 31155311DOI: 10.1016/j.str.2019.04.015 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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