6MQN

Crystal structure of KRAS V14I-GDP demonstrating disorder switch 1 conformation - Form 2

Summary for 6MQN

Entry DOI	10.2210/pdb6mqn/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	gtpase kras hydrolysis, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	59186.96
Authors	Bera, A.K.,Westover, K.D. (deposition date: 2018-10-10, release date: 2019-07-31, Last modification date: 2023-10-11)
Primary citation	Bera, A.K.,Lu, J.,Wales, T.E.,Gondi, S.,Gurbani, D.,Nelson, A.,Engen, J.R.,Westover, K.D. Structural basis of the atypical activation mechanism of KRASV14I. J.Biol.Chem., 294:13964-13972, 2019 Cited by PubMed: 31341022 DOI: 10.1074/jbc.RA119.009131 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation