6MPG

Cryo-EM structure at 3.2 A resolution of HIV-1 fusion peptide-directed antibody, A12V163-b.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122

これはPDB形式変換不可エントリーです。

6MPG の概要

• エントリーDOI: 10.2210/pdb6mpg/pdb
• EMDBエントリー: 8977
• 分子名称: A12V163-b.01 Light Chain, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• 機能のキーワード: complex, fusion peptide, neutralizing antibody, hiv-1 envelope, viral protein
• 由来する生物種: Macaca mulatta; 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 502651.69

構造登録者

Acharya, P.,Kwong, P.D. (登録日: 2018-10-06, 公開日: 2019-07-24, 最終更新日: 2020-07-29)

• 主引用文献: Kong, R.,Duan, H.,Sheng, Z.,Xu, K.,Acharya, P.,Chen, X.,Cheng, C.,Dingens, A.S.,Gorman, J.,Sastry, M.,Shen, C.H.,Zhang, B.,Zhou, T.,Chuang, G.Y.,Chao, C.W.,Gu, Y.,Jafari, A.J.,Louder, M.K.,O'Dell, S.,Rowshan, A.P.,Viox, E.G.,Wang, Y.,Choi, C.W.,Corcoran, M.M.,Corrigan, A.R.,Dandey, V.P.,Eng, E.T.,Geng, H.,Foulds, K.E.,Guo, Y.,Kwon, Y.D.,Lin, B.,Liu, K.,Mason, R.D.,Nason, M.C.,Ohr, T.Y.,Ou, L.,Rawi, R.,Sarfo, E.K.,Schon, A.,Todd, J.P.,Wang, S.,Wei, H.,Wu, W.,Mullikin, J.C.,Bailer, R.T.,Doria-Rose, N.A.,Karlsson Hedestam, G.B.,Scorpio, D.G.,Overbaugh, J.,Bloom, J.D.,Carragher, B.,Potter, C.S.,Shapiro, L.,Kwong, P.D.,Mascola, J.R.; Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.; Cell, 178:567-584.e19, 2019; PubMed: 31348886; DOI: 10.1016/j.cell.2019.06.030

実験手法

ELECTRON MICROSCOPY (3.2 Å)