6MOD

Co-Crystal structure of P. aeruginosa LpxC-50432 complex

6MOD の概要

• エントリーDOI: 10.2210/pdb6mod/pdb
• 分子名称: UDP-3-O-acyl-N-acetylglucosamine deacetylase, MAGNESIUM ION, N-[(1S)-2-(hydroxyamino)-1-(3-methoxy-1,1-dioxo-1lambda~6~-thietan-3-yl)-2-oxoethyl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide, ... (5 entities in total)
• 機能のキーワード: hydrolase lpxc pseudomonas aeruginosa, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34371.16

構造登録者

Stein, A.J.,Holt, M.C.,Assar, Z.,Cohen, F.,Andrews, L.,Cirz, R. (登録日: 2018-10-04, 公開日: 2019-07-17, 最終更新日: 2024-03-13)

• 主引用文献: Cohen, F.,Aggen, J.B.,Andrews, L.D.,Assar, Z.,Boggs, J.,Choi, T.,Dozzo, P.,Easterday, A.N.,Haglund, C.M.,Hildebrandt, D.J.,Holt, M.C.,Joly, K.,Jubb, A.,Kamal, Z.,Kane, T.R.,Konradi, A.W.,Krause, K.M.,Linsell, M.S.,Machajewski, T.D.,Miroshnikova, O.,Moser, H.E.,Nieto, V.,Phan, T.,Plato, C.,Serio, A.W.,Seroogy, J.,Shakhmin, A.,Stein, A.J.,Sun, A.D.,Sviridov, S.,Wang, Z.,Wlasichuk, K.,Yang, W.,Zhou, X.,Zhu, H.,Cirz, R.T.; Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.; Chemmedchem, 14:1560-1572, 2019; PubMed: 31283109; DOI: 10.1002/cmdc.201900287

実験手法

X-RAY DIFFRACTION (1.85 Å)