6MO1

Structure of dengue virus protease with an allosteric Inhibitor that blocks replication

6MO1 の概要

• エントリーDOI: 10.2210/pdb6mo1/pdb
• 分子名称: FLAVIVIRUS_NS2B/Peptidase S7, 5-[4-(aminomethyl)phenyl]-6-[4-(furan-3-yl)phenyl]-N-[(piperidin-4-yl)methyl]pyrazin-2-amine (2 entities in total)
• 機能のキーワード: allosteric inhibitor, inhibitor, complex, protease, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Dengue virus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53540.10

構造登録者

Lin, Y.-L.,Hua, Y.,Nie, S.,Wu, J.,Wu, F.,Huo, T.,Yao, Y.,Song, Y. (登録日: 2018-10-03, 公開日: 2019-05-15, 最終更新日: 2023-10-11)

• 主引用文献: Yao, Y.,Huo, T.,Lin, Y.L.,Nie, S.,Wu, F.,Hua, Y.,Wu, J.,Kneubehl, A.R.,Vogt, M.B.,Rico-Hesse, R.,Song, Y.; Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.; J.Am.Chem.Soc., 141:6832-6836, 2019; PubMed: 31017399; DOI: 10.1021/jacs.9b02505

実験手法

X-RAY DIFFRACTION (3 Å)