6MNL
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
Summary for 6MNL
Entry DOI | 10.2210/pdb6mnl/pdb |
NMR Information | BMRB: 30373 |
Descriptor | FOXO3a peptide, Bromodomain-containing protein 4 (2 entities in total) |
Functional Keywords | brd4, cdk6, akt, luminal breast cancer, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 16595.01 |
Authors | Zeng, L.,Zhou, M.-M. (deposition date: 2018-10-02, release date: 2018-10-31, Last modification date: 2023-11-15) |
Primary citation | Liu, J.,Duan, Z.,Guo, W.,Zeng, L.,Wu, Y.,Chen, Y.,Tai, F.,Wang, Y.,Lin, Y.,Zhang, Q.,He, Y.,Deng, J.,Stewart, R.L.,Wang, C.,Lin, P.C.,Ghaffari, S.,Evers, B.M.,Liu, S.,Zhou, M.M.,Zhou, B.P.,Shi, J. Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer. Nat Commun, 9:5200-5200, 2018 Cited by PubMed: 30518851DOI: 10.1038/s41467-018-07258-y PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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