6MNL

NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide

Summary for 6MNL

• Entry DOI: 10.2210/pdb6mnl/pdb
• NMR Information: BMRB: 30373
• Descriptor: FOXO3a peptide, Bromodomain-containing protein 4 (2 entities in total)
• Functional Keywords: brd4, cdk6, akt, luminal breast cancer, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 16595.01

Authors

Zeng, L.,Zhou, M.-M. (deposition date: 2018-10-02, release date: 2018-10-31, Last modification date: 2023-11-15)

• Primary citation: Liu, J.,Duan, Z.,Guo, W.,Zeng, L.,Wu, Y.,Chen, Y.,Tai, F.,Wang, Y.,Lin, Y.,Zhang, Q.,He, Y.,Deng, J.,Stewart, R.L.,Wang, C.,Lin, P.C.,Ghaffari, S.,Evers, B.M.,Liu, S.,Zhou, M.M.,Zhou, B.P.,Shi, J.; Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.; Nat Commun, 9:5200-5200, 2018; PubMed: 30518851; DOI: 10.1038/s41467-018-07258-y

Experimental method

SOLUTION NMR