6MKK
Crystallographic solvent mapping analysis of DMSO/Mg bound to APE1
Summary for 6MKK
Entry DOI | 10.2210/pdb6mkk/pdb |
Descriptor | DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | apurinic/apyrimidinic endonuclease, dna repair, abasic site, solvent mapping, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32300.02 |
Authors | Georgiadis, M.M.,He, H.,Chen, Q. (deposition date: 2018-09-25, release date: 2019-01-30, Last modification date: 2024-03-13) |
Primary citation | Trilles, R.,Beglov, D.,Chen, Q.,He, H.,Wireman, R.,Reed, A.,Chennamadhavuni, S.,Panek, J.S.,Brown, L.E.,Vajda, S.,Porco Jr., J.A.,Kelley, M.R.,Georgiadis, M.M. Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. J. Med. Chem., 62:1971-1988, 2019 Cited by PubMed: 30653918DOI: 10.1021/acs.jmedchem.8b01529 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.442 Å) |
Structure validation
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