6MKH

Crystal structure of pencillin binding protein 4 (PBP4) from Enterococcus faecalis in the imipenem-bound form

6MKH の概要

• エントリーDOI: 10.2210/pdb6mkh/pdb
• 分子名称: pencillin binding protein 4 (PBP4), (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: pbp, antibiotic, inhibitor, imipenem, penicillin-binding protein, protein binding-antibiotic complex, protein binding/antibiotic
• 由来する生物種: Enterococcus faecalis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 71200.41

構造登録者

D'Andrea, E.D.,Moon, T.M.,Peti, W.,Page, R. (登録日: 2018-09-25, 公開日: 2018-10-31, 最終更新日: 2024-04-03)

• 主引用文献: Moon, T.M.,D'Andrea, E.D.,Lee, C.W.,Soares, A.,Jakoncic, J.,Desbonnet, C.,Garcia-Solache, M.,Rice, L.B.,Page, R.,Peti, W.; The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance.; J. Biol. Chem., 293:18574-18584, 2018; PubMed: 30355734; DOI: 10.1074/jbc.RA118.006052

実験手法

X-RAY DIFFRACTION (2.62 Å)