6MJW

human cGAS catalytic domain bound with the inhibitor G150

6MJW の概要

• エントリーDOI: 10.2210/pdb6mjw/pdb
• 分子名称: Cyclic GMP-AMP synthase, ZINC ION, 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, ... (4 entities in total)
• 機能のキーワード: human cgas, dna sensor, inhibitor, immune system, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43942.71

構造登録者

Lama, L.,Adura, C.,Xie, W.,Tomita, D.,Kamei, T.,Kuryavyi, V.,Gogakos, T.,Steinberg, J.I.,Miller, M.,Ramos-Espiritu, L.,Asano, Y.,Hashizume, S.,Aida, J.,Imaeda, T.,Okamoto, R.,Jennings, A.J.,Michinom, M.,Kuroita, T.,Stamford, A.,Gao, P.,Meinke, P.,Glickman, J.F.,Patel, D.J.,Tuschl, T. (登録日: 2018-09-23, 公開日: 2019-05-29, 最終更新日: 2024-03-13)

• 主引用文献: Lama, L.,Adura, C.,Xie, W.,Tomita, D.,Kamei, T.,Kuryavyi, V.,Gogakos, T.,Steinberg, J.I.,Miller, M.,Ramos-Espiritu, L.,Asano, Y.,Hashizume, S.,Aida, J.,Imaeda, T.,Okamoto, R.,Jennings, A.J.,Michino, M.,Kuroita, T.,Stamford, A.,Gao, P.,Meinke, P.,Glickman, J.F.,Patel, D.J.,Tuschl, T.; Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.; Nat Commun, 10:2261-2261, 2019; PubMed: 31113940; DOI: 10.1038/s41467-019-08620-4

実験手法

X-RAY DIFFRACTION (2.405 Å)