6MHM
Crystal structure of human acid ceramidase in covalent complex with carmofur
Summary for 6MHM
Entry DOI | 10.2210/pdb6mhm/pdb |
Related PRD ID | PRD_900017 |
Descriptor | Acid ceramidase subunit alpha, Acid ceramidase subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | acid ceramidase, acid ceramidase inhibitors, benzoxazolone carboxamides, carmofur, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 92452.01 |
Authors | Dementiev, A.,Joachimiak, A.,Doan, N. (deposition date: 2018-09-18, release date: 2019-01-23, Last modification date: 2023-10-11) |
Primary citation | Dementiev, A.,Joachimiak, A.,Nguyen, H.,Gorelik, A.,Illes, K.,Shabani, S.,Gelsomino, M.,Ahn, E.E.,Nagar, B.,Doan, N. Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur. J. Med. Chem., 62:987-992, 2019 Cited by PubMed: 30525581DOI: 10.1021/acs.jmedchem.8b01723 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.743 Å) |
Structure validation
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