6MHM

Crystal structure of human acid ceramidase in covalent complex with carmofur

6MHM の概要

• エントリーDOI: 10.2210/pdb6mhm/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900017
• 分子名称: Acid ceramidase subunit alpha, Acid ceramidase subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: acid ceramidase, acid ceramidase inhibitors, benzoxazolone carboxamides, carmofur, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92452.01

構造登録者

Dementiev, A.,Joachimiak, A.,Doan, N. (登録日: 2018-09-18, 公開日: 2019-01-23, 最終更新日: 2023-10-11)

• 主引用文献: Dementiev, A.,Joachimiak, A.,Nguyen, H.,Gorelik, A.,Illes, K.,Shabani, S.,Gelsomino, M.,Ahn, E.E.,Nagar, B.,Doan, N.; Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.; J. Med. Chem., 62:987-992, 2019; PubMed: 30525581; DOI: 10.1021/acs.jmedchem.8b01723

実験手法

X-RAY DIFFRACTION (2.743 Å)