6MH7
Crystal structure of the first bromodomain of human BRD4 in complex with SKT-68, a 1,4,5-trisubstituted imidazole analogue
6MH7 の概要
エントリーDOI | 10.2210/pdb6mh7/pdb |
分子名称 | Bromodomain-containing protein 4, N-(3,4-dimethylphenyl)-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine, DIMETHYL SULFOXIDE, ... (5 entities in total) |
機能のキーワード | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, inhibitor, transcription-inhibitor complex, inflammation, 19f-nmr, map-kinase inhibition, protein binding/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 31410.23 |
構造登録者 | |
主引用文献 | Divakaran, A.,Talluri, S.K.,Ayoub, A.M.,Mishra, N.K.,Cui, H.,Widen, J.C.,Berndt, N.,Zhu, J.Y.,Carlson, A.S.,Topczewski, J.J.,Schonbrunn, E.K.,Harki, D.A.,Pomerantz, W.C.K. Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J.Med.Chem., 61:9316-9334, 2018 Cited by PubMed: 30253095DOI: 10.1021/acs.jmedchem.8b01248 主引用文献が同じPDBエントリー |
実験手法 |
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