6MH5
Crystal Structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Staphylococcus schleiferi in complex with Fosmidomycin (FOM)
Summary for 6MH5
Entry DOI | 10.2210/pdb6mh5/pdb |
Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID (2 entities in total) |
Functional Keywords | reductoisomerase, staphylococci, mep pathway, fosmidomycin, glpt, oxidoreductase |
Biological source | Staphylococcus schleiferi |
Total number of polymer chains | 2 |
Total formula weight | 84863.05 |
Authors | |
Primary citation | Edwards, R.L.,Heueck, I.,Lee, S.G.,Shah, I.T.,Miller, J.J.,Jezewski, A.J.,Mikati, M.O.,Wang, X.,Brothers, R.C.,Heidel, K.M.,Osbourn, D.M.,Burnham, C.D.,Alvarez, S.,Fritz, S.A.,Dowd, C.S.,Jez, J.M.,Odom John, A.R. Potent, specific MEPicides for treatment of zoonotic staphylococci. Plos Pathog., 16:e1007806-e1007806, 2020 Cited by PubMed: 32497104DOI: 10.1371/journal.ppat.1007806 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.887 Å) |
Structure validation
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