6MH5

Crystal Structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Staphylococcus schleiferi in complex with Fosmidomycin (FOM)

6MH5 の概要

• エントリーDOI: 10.2210/pdb6mh5/pdb
• 分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID (2 entities in total)
• 機能のキーワード: reductoisomerase, staphylococci, mep pathway, fosmidomycin, glpt, oxidoreductase
• 由来する生物種: Staphylococcus schleiferi
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84863.05

構造登録者

Lee, S.G.,Jez, J.M. (登録日: 2018-09-17, 公開日: 2020-03-18, 最終更新日: 2024-03-13)

• 主引用文献: Edwards, R.L.,Heueck, I.,Lee, S.G.,Shah, I.T.,Miller, J.J.,Jezewski, A.J.,Mikati, M.O.,Wang, X.,Brothers, R.C.,Heidel, K.M.,Osbourn, D.M.,Burnham, C.D.,Alvarez, S.,Fritz, S.A.,Dowd, C.S.,Jez, J.M.,Odom John, A.R.; Potent, specific MEPicides for treatment of zoonotic staphylococci.; Plos Pathog., 16:e1007806-e1007806, 2020; PubMed: 32497104; DOI: 10.1371/journal.ppat.1007806

実験手法

X-RAY DIFFRACTION (2.887 Å)