6MG7

Crystal structure of the RV144 C1-C2 specific antibody CH54 Fab in complex with HIV-1 CLADE A/E GP120 and M48U1

Summary for 6MG7

• Entry DOI: 10.2210/pdb6mg7/pdb
• Related PRD ID: PRD_001094
• Descriptor: clade A/E 93TH057 HIV-1 gp120 core, M48U1 CD4 mimetic peptide, CH54 Fab heavy chain, ... (5 entities in total)
• Functional Keywords: anti-hiv-1 env antibody ch54, cd4i antibody, adcc, hiv-1 env, immune system, rv144 vaccine trial, clade a/e 93th057, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 4
• Total formula weight: 94286.22

Authors

Van, V.,Tolbert, W.D.,Pazgier, M. (deposition date: 2018-09-13, release date: 2019-09-25, Last modification date: 2023-11-15)

• Primary citation: Tolbert, W.D.,Van, V.,Sherburn, R.,Tuyishime, M.,Yan, F.,Nguyen, D.N.,Stanfield-Oakley, S.,Easterhoff, D.,Bonsignori, M.,Haynes, B.F.,Moody, M.A.,Ray, K.,Ferrari, G.,Lewis, G.K.,Pazgier, M.; Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial.; Mbio, 11:-, 2020; PubMed: 32605979; DOI: 10.1128/mBio.00208-20

Experimental method

X-RAY DIFFRACTION (2.91 Å)