6MFW
Crystal structure of a 4-domain construct of LgrA in the substrate donation state
Summary for 6MFW
Entry DOI | 10.2210/pdb6mfw/pdb |
Descriptor | Linear gramicidin synthase subunit A, (2~{R})-~{N}-[3-[2-[[(2~{S})-2-formamido-3-methyl-butanoyl]amino]ethylamino]-3-oxidanylidene-propyl]-3,3-dimethyl-2-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-butanamide, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, ... (8 entities in total) |
Functional Keywords | nonribosomal peptide synthetase, tailoring domain, nrps, enzyme, natural product, linear gramicidin, ligase |
Biological source | Brevibacillus parabrevis |
Total number of polymer chains | 1 |
Total formula weight | 139739.89 |
Authors | Reimer, J.M.,Eivaskhani, M.,Schmeing, T.M. (deposition date: 2018-09-12, release date: 2019-11-20, Last modification date: 2023-10-11) |
Primary citation | Reimer, J.M.,Eivaskhani, M.,Harb, I.,Guarne, A.,Weigt, M.,Schmeing, T.M. Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science, 366:-, 2019 Cited by PubMed: 31699907DOI: 10.1126/science.aaw4388 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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