6MFW

Crystal structure of a 4-domain construct of LgrA in the substrate donation state

6MFW の概要

• エントリーDOI: 10.2210/pdb6mfw/pdb
• 分子名称: Linear gramicidin synthase subunit A, (2~{R})-~{N}-[3-[2-[[(2~{S})-2-formamido-3-methyl-butanoyl]amino]ethylamino]-3-oxidanylidene-propyl]-3,3-dimethyl-2-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-butanamide, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, ... (8 entities in total)
• 機能のキーワード: nonribosomal peptide synthetase, tailoring domain, nrps, enzyme, natural product, linear gramicidin, ligase
• 由来する生物種: Brevibacillus parabrevis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 139739.89

構造登録者

Reimer, J.M.,Eivaskhani, M.,Schmeing, T.M. (登録日: 2018-09-12, 公開日: 2019-11-20, 最終更新日: 2023-10-11)

• 主引用文献: Reimer, J.M.,Eivaskhani, M.,Harb, I.,Guarne, A.,Weigt, M.,Schmeing, T.M.; Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.; Science, 366:-, 2019; PubMed: 31699907; DOI: 10.1126/science.aaw4388

実験手法

X-RAY DIFFRACTION (2.5 Å)