6MFI

MIM-2 Metallo-Beta-Lactamase

6MFI の概要

• エントリーDOI: 10.2210/pdb6mfi/pdb
• 分子名称: Metallo-beta-lactamase, ZINC ION (3 entities in total)
• 機能のキーワード: metallohydrolase, hydrolase, b3
• 由来する生物種: Simiduia agarivorans (strain DSM 21679 / JCM 13881 / BCRC 17597 / SA1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31488.18

構造登録者

Selleck, C.,Guddat, L.,Schenk, G.,Monteiro Pedroso, M. (登録日: 2018-09-11, 公開日: 2019-11-13, 最終更新日: 2024-11-20)

主引用文献

Selleck, C.,Clayton, D.,Gahan, L.R.,Mitic, N.,McGeary, R.P.,Pedroso, M.M.,Guddat, L.W.,Schenk, G.,Monteiro Pedroso, M.
characterization of the B3 MBLs MIM-1 and MIM-2 from environmental microorganisms.
Chemistry, 23:4778-4781, 2017

PubMed Abstract: Metallohydrolases are a vast family of enzymes that play crucial roles in numerous metabolic pathways. Several members have emerged as targets for chemotherapeutics. Knowledge about their reaction mechanisms and associated transition states greatly aids the design of potent and highly specific drug leads. By using a high-resolution crystal structure, we have probed the trajectory of the reaction catalyzed by purple acid phosphatase, an enzyme essential for the integrity of bone structure. In particular, the transition state is visualized, thus providing detailed structural information that may be exploited in the design of specific inhibitors for the development of new anti-osteoporotic chemotherapeutics.

PubMed: 28261912
DOI: 10.1002/chem.201700866

実験手法

X-RAY DIFFRACTION (1.839 Å)