6MFE

Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0000773 (Compound 11g) Complex

Summary for 6MFE

Entry DOI	10.2210/pdb6mfe/pdb
Descriptor	Sulfotransferase oxamniquine resistance protein, ADENOSINE-3'-5'-DIPHOSPHATE, (2-nitro-4-{[(3S)-1-{[4-(trifluoromethoxy)phenyl]methyl}pyrrolidin-3-yl]amino}phenyl)methanol, ... (4 entities in total)
Functional Keywords	sulfotransferase, parasite, drug resistance, transferase
Biological source	Schistosoma mansoni (Blood fluke)
Total number of polymer chains	1
Total formula weight	30919.12
Authors	Taylor, A.B. (deposition date: 2018-09-10, release date: 2018-10-03, Last modification date: 2023-10-11)
Primary citation	Rugel, A.,Tarpley, R.S.,Lopez, A.,Menard, T.,Guzman, M.A.,Taylor, A.B.,Cao, X.,Kovalskyy, D.,Chevalier, F.D.,Anderson, T.J.C.,Hart, P.J.,LoVerde, P.T.,McHardy, S.F. Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents. ACS Med Chem Lett, 9:967-973, 2018 Cited by PubMed: 30344901 DOI: 10.1021/acsmedchemlett.8b00257 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.444 Å)

Structure validation