6MD7
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7
Summary for 6MD7
Entry DOI | 10.2210/pdb6md7/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 2-[4-(aminomethyl)-4-methylpiperidin-1-yl]-5-{[2-(trifluoromethyl)pyridin-3-yl]sulfanyl}pyrimidin-4(3H)-one, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 122513.62 |
Authors | |
Primary citation | Sarver, P.,Acker, M.,Bagdanoff, J.T.,Chen, Z.,Chen, Y.N.,Chan, H.,Firestone, B.,Fodor, M.,Fortanet, J.,Hao, H.,Hentemann, M.,Kato, M.,Koenig, R.,LaBonte, L.R.,Liu, G.,Liu, S.,Liu, C.,McNeill, E.,Mohseni, M.,Sendzik, M.,Stams, T.,Spence, S.,Tamez, V.,Tichkule, R.,Towler, C.,Wang, H.,Wang, P.,Williams, S.L.,Yu, B.,LaMarche, M.J. 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J. Med. Chem., 62:1793-1802, 2019 Cited by PubMed: 30688459DOI: 10.1021/acs.jmedchem.8b01726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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