6M9W

Structure of Mg-free KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation

6M9W の概要

• エントリーDOI: 10.2210/pdb6m9w/pdb
• 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
• 機能のキーワード: kras, ras, mg, k-ras-4b, small gtpase, guanine nucleotide, oncoprotein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19697.87

構造登録者

Dharmaiah, S.,Tran, T.H.,Yan, W.,Simanshu, D.K. (登録日: 2018-08-24, 公開日: 2019-07-31, 最終更新日: 2023-10-11)

• 主引用文献: Dharmaiah, S.,Tran, T.H.,Messing, S.,Agamasu, C.,Gillette, W.K.,Yan, W.,Waybright, T.,Alexander, P.,Esposito, D.,Nissley, D.V.,McCormick, F.,Stephen, A.G.,Simanshu, D.K.; Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.; Sci Rep, 9:10512-10512, 2019; PubMed: 31324887; DOI: 10.1038/s41598-019-46846-w

実験手法

X-RAY DIFFRACTION (1.5 Å)