6M9L
Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10
6M9L の概要
エントリーDOI | 10.2210/pdb6m9l/pdb |
分子名称 | Mitogen-activated protein kinase 14, 3-benzyl-6-[(2,4-difluorophenyl)amino]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (3 entities in total) |
機能のキーワード | sbdd, structure based drug design, p38, kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 45057.08 |
構造登録者 | |
主引用文献 | Kaieda, A.,Takahashi, M.,Fukuda, H.,Okamoto, R.,Morimoto, S.,Gotoh, M.,Miyazaki, T.,Hori, Y.,Unno, S.,Kawamoto, T.,Tanaka, T.,Itono, S.,Takagi, T.,Sugimoto, H.,Okada, K.,Snell, G.,Bertsch, R.,Nguyen, J.,Sang, B.C.,Miwatashi, S. Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14:1022-1030, 2019 Cited by PubMed: 30945818DOI: 10.1002/cmdc.201900129 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.45 Å) |
構造検証レポート
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