6M8E
Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with rhamnetin
Summary for 6M8E
Entry DOI | 10.2210/pdb6m8e/pdb |
Descriptor | Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1-benzopyran-4-one (3 entities in total) |
Functional Keywords | kinase, inositol, inositol polyphosphate, transferase, rhamnetin, flavonoid, inhibitor, natural product, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 30144.17 |
Authors | Wang, H.,Shears, S.B. (deposition date: 2018-08-21, release date: 2019-01-23, Last modification date: 2023-10-11) |
Primary citation | Gu, C.,Stashko, M.A.,Puhl-Rubio, A.C.,Chakraborty, M.,Chakraborty, A.,Frye, S.V.,Pearce, K.H.,Wang, X.,Shears, S.B.,Wang, H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J. Med. Chem., 62:1443-1454, 2019 Cited by PubMed: 30624931DOI: 10.1021/acs.jmedchem.8b01593 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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