6M8A

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with luteolin

6M8A の概要

• エントリーDOI: 10.2210/pdb6m8a/pdb
• 関連するPDBエントリー: 5w2g
• 分子名称: Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (3 entities in total)
• 機能のキーワード: kinase, inositol, inositol polyphosphate, transferase, luteolin, flavonoid, inhibitor, natural product, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30114.15

構造登録者

Wang, H.,Shears, S.B. (登録日: 2018-08-21, 公開日: 2019-01-23, 最終更新日: 2023-10-11)

• 主引用文献: Gu, C.,Stashko, M.A.,Puhl-Rubio, A.C.,Chakraborty, M.,Chakraborty, A.,Frye, S.V.,Pearce, K.H.,Wang, X.,Shears, S.B.,Wang, H.; Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.; J. Med. Chem., 62:1443-1454, 2019; PubMed: 30624931; DOI: 10.1021/acs.jmedchem.8b01593

実験手法

X-RAY DIFFRACTION (1.75 Å)