6M7I

Crystal structure of KPC-2 with compound 3

Summary for 6M7I

Entry DOI	10.2210/pdb6m7i/pdb
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, 1-(2,4-dichlorophenyl)-4-(1H-tetrazol-5-yl)-1H-pyrazol-5-amine, GLYCEROL, ... (4 entities in total)
Functional Keywords	carbapenemase, tetrazole, inhibitor, complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	32083.19
Authors	Akhtar, A.,Chen, Y. (deposition date: 2018-08-20, release date: 2019-04-17, Last modification date: 2023-10-11)
Primary citation	Torelli, N.J.,Akhtar, A.,DeFrees, K.,Jaishankar, P.,Pemberton, O.A.,Zhang, X.,Johnson, C.,Renslo, A.R.,Chen, Y. Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. Acs Infect Dis., 5:1013-1021, 2019 Cited by PubMed: 30942078 DOI: 10.1021/acsinfecdis.9b00052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.701 Å)

Structure validation