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6M0K

The crystal structure of COVID-19 main protease in complex with an inhibitor 11b

Summary for 6M0K
Entry DOI10.2210/pdb6m0k/pdb
Related PRD IDPRD_002349
Descriptor3C-like proteinase, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-(3-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide, ... (4 entities in total)
Functional Keywordsprotease, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains1
Total formula weight34327.27
Authors
Zhang, B.,Zhao, Y.,Jin, Z.,Liu, X.,Yang, H.,Liu, H.,Rao, Z.,Jiang, H. (deposition date: 2020-02-22, release date: 2020-04-29, Last modification date: 2023-11-29)
Primary citationDai, W.,Zhang, B.,Jiang, X.M.,Su, H.,Li, J.,Zhao, Y.,Xie, X.,Jin, Z.,Peng, J.,Liu, F.,Li, C.,Li, Y.,Bai, F.,Wang, H.,Cheng, X.,Cen, X.,Hu, S.,Yang, X.,Wang, J.,Liu, X.,Xiao, G.,Jiang, H.,Rao, Z.,Zhang, L.K.,Xu, Y.,Yang, H.,Liu, H.
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Science, 368:1331-1335, 2020
Cited by
PubMed: 32321856
DOI: 10.1126/science.abb4489
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.504 Å)
Structure validation

217705

数据于2024-03-27公开中

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