6LWO
Crystal structure of human NEIL1(R242, Y244H) bound to duplex DNA containing 2'-fluoro-2'-deoxy-5,6-dihydrouridine
Summary for 6LWO
Entry DOI | 10.2210/pdb6lwo/pdb |
Descriptor | Endonuclease 8-like 1, DNA (5'-D(*CP*GP*TP*CP*CP*AP*(FDU)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3'), ... (5 entities in total) |
Functional Keywords | base lesion, oxidative dna damage, dna repair, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 9 |
Total formula weight | 123780.16 |
Authors | |
Primary citation | Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun, 12:4108-4108, 2021 Cited by PubMed: 34226550DOI: 10.1038/s41467-021-24431-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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