6LW2
The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase
Summary for 6LW2
Entry DOI | 10.2210/pdb6lw2/pdb |
Descriptor | Fructose-1,6-bisphosphatase 1, 7-chloranyl-4-[(3-methoxyphenyl)amino]-N-(4-methoxyphenyl)sulfonyl-1-methyl-indole-2-carboxamide (3 entities in total) |
Functional Keywords | fbpase, n-arylsulfonyl-indole-2-carboxamide, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 149549.60 |
Authors | Wang, X.Y.,Zhou, J.,Xu, B.L. (deposition date: 2020-02-07, release date: 2020-05-13, Last modification date: 2023-11-29) |
Primary citation | Zhou, J.,Bie, J.,Wang, X.,Liu, Q.,Li, R.,Chen, H.,Hu, J.,Cao, H.,Ji, W.,Li, Y.,Liu, S.,Shen, Z.,Xu, B. Discovery of N -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis. J.Med.Chem., 63:10307-10329, 2020 Cited by PubMed: 32820629DOI: 10.1021/acs.jmedchem.0c00726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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