6LW2

The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase

Summary for 6LW2

Entry DOI	10.2210/pdb6lw2/pdb
Descriptor	Fructose-1,6-bisphosphatase 1, 7-chloranyl-4-[(3-methoxyphenyl)amino]-N-(4-methoxyphenyl)sulfonyl-1-methyl-indole-2-carboxamide (3 entities in total)
Functional Keywords	fbpase, n-arylsulfonyl-indole-2-carboxamide, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	149549.60
Authors	Wang, X.Y.,Zhou, J.,Xu, B.L. (deposition date: 2020-02-07, release date: 2020-05-13, Last modification date: 2023-11-29)
Primary citation	Zhou, J.,Bie, J.,Wang, X.,Liu, Q.,Li, R.,Chen, H.,Hu, J.,Cao, H.,Ji, W.,Li, Y.,Liu, S.,Shen, Z.,Xu, B. Discovery of N -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis. J.Med.Chem., 63:10307-10329, 2020 Cited by PubMed: 32820629 DOI: 10.1021/acs.jmedchem.0c00726 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation