6LVX

Crystal structure of TLR7/Cpd-1 (SM-374527) complex

Summary for 6LVX

Entry DOI	10.2210/pdb6lvx/pdb
Descriptor	Toll-like receptor 7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... (6 entities in total)
Functional Keywords	tlr7, agonist, immune system
Biological source	Macaca mulatta (Rhesus macaque)
Total number of polymer chains	2
Total formula weight	193551.96
Authors	Zhang, Z.,Ohto, U.,Shimizu, T. (deposition date: 2020-02-06, release date: 2020-11-11, Last modification date: 2023-11-29)
Primary citation	Tojo, S.,Zhang, Z.,Matsui, H.,Tahara, M.,Ikeguchi, M.,Kochi, M.,Kamada, M.,Shigematsu, H.,Tsutsumi, A.,Adachi, N.,Shibata, T.,Yamamoto, M.,Kikkawa, M.,Senda, T.,Isobe, Y.,Ohto, U.,Shimizu, T. Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11:5204-5204, 2020 Cited by PubMed: 33060576 DOI: 10.1038/s41467-020-19025-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.77 Å)

Structure validation